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| Status |
Public on Oct 14, 2015 |
| Title |
Genome-wide analysis of gene expression in MDA-MB-231 cells treated with cholesterol synthesis inhibitors |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
The hypothesis tested in this experiment was that a statin caused a larger shift in genes associated with pluripotency when compared with a Δ-24 oxidoreductase. It was theorized that the effect of the statin would be greater since the enzyme inhibition takes place proximal to the pathway branch involved in signal isoprenylation, whereas the oxidoreductase inhibits distal to this branch.
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| |
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| Overall design |
Total RNA was obtained from MDA-MB-231 cells following 24 hour exposure to Pravastatin or Proadifen hydrochloride
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| |
|
| Contributor(s) |
Garnett DJ |
| Citation(s) |
26573510 |
| Submission date |
May 29, 2013 |
| Last update date |
Aug 13, 2018 |
| Contact name |
Andrew Canter |
| E-mail(s) |
andy@pathway-intermediates.com
|
| Organization name |
Pathway Intermediates
|
| Street address |
Unti 46, Atcham Business Park
|
| City |
Shrewsbury |
| ZIP/Postal code |
SY4 4UG |
| Country |
United Kingdom |
| |
|
| Platforms (1) |
| GPL10558 |
Illumina HumanHT-12 V4.0 expression beadchip |
|
| Samples (12)
|
| GSM1150548 |
MDA-MB-231 treated with 0.0008% (w/v) Proadifen [A1] |
| GSM1150549 |
MDA-MB-231 treated with 0.0008% (w/v) Proadifen [A2] |
| GSM1150550 |
MDA-MB-231 treated with 0.0008% (w/v) Proadifen [A3] |
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| This SubSeries is part of SuperSeries: |
| GSE47463 |
Genome-wide analysis of gene expression in cells treated with cholesterol synthesis inhibitors |
|
| Relations |
| BioProject |
PRJNA205695 |
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