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Series GSE47471 Query DataSets for GSE47471
Status Public on Oct 23, 2013
Title TCTP is an androgen-regulated gene implicated in prostate cancer
Organism Homo sapiens
Experiment type Expression profiling by array
Summary TCTP has been implicated in a plethora of important cellular processes related to cell growth, cell cycle progression, malignant transformation and inhibition of apoptosis. In addition to these intracellular functions, TCTP has extracellular functions and plays an important role in immune cells. TCTP expression was previously shown to be deregulated in prostate cancer, but its function in prostate cancer cells is largely unknown. Here we show that TCTP expression is regulated by androgens in LNCaP prostate cancer cells in vitro as well as human prostate cancer xenografts in vivo. Knockdown of TCTP reduced colony formation and increased apoptosis in LNCaP cells, implicating it as an important factor for prostate cancer cell growth. Global gene expression profiling in TCTP knockdown LNCaP cells showed that several interferon regulated genes are regulated by TCTP, suggesting that it may have a role in regulating immune function in prostate cancer. In addition, recombinant TCTP treatment increased colony formation in LNCaP cells suggesting that secreted TCTP may function as a proliferative factor in prostate cancer. These results suggest that TCTP may have a role in prostate cancer development.
 
Overall design A total of 6 samples were analyzed. These consisted of three biological replicates for each treatment. The samples transfected with siRNA against Luciferase (siLuc) served as controls.
 
Contributor(s) Kaarbø M, Storm M, Qu S, Wæhre H, Risberg B, Danielsen HE, Saatcioglu F
Citation(s) 23894469
Submission date May 29, 2013
Last update date Feb 18, 2019
Contact name Margrethe Storm
Organization name University of Oslo
Street address Blindernveien 31
City Oslo
ZIP/Postal code 0316
Country Norway
 
Platforms (1)
GPL6884 Illumina HumanWG-6 v3.0 expression beadchip
Samples (6)
GSM1150683 siLuc 1
GSM1150684 siLuc 2
GSM1150685 siLuc 3
Relations
BioProject PRJNA205827

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE47471_RAW.tar 6.3 Mb (http)(custom) TAR
GSE47471_non-normalized.txt.gz 2.0 Mb (ftp)(http) TXT
Processed data included within Sample table

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