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| Status |
Public on May 31, 2013 |
| Title |
The physicochemistry of capped nanosilver predicts it biological activity in brain endothelial (RBEC4) cells |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by array
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| Summary |
This study uses the RBEC4 cell model to examine if nanosilver of different sizes (10nm and 75nm) and cappings (citrate and polyvinylpyrrolidone(PVP)) affect its cellular permeability and genomic response.
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| Overall design |
RBEC4 cells (95% confluent) were screeened for changes in gene expression after 18 hour exposure to 1.0 ppm of PVP or citrate coated nanosilver particles at 10 or 75 nanometer sizes. Analysis indicated that the cellular transcription profile alter by nanosilver 10nm+PVP was distinct from it 75nm counterpart and both sizes of citrate-coated particles.
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| Contributor(s) |
Veronesi B, Chorley B, Valant B, Ward W |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
May 30, 2013 |
| Last update date |
Jul 29, 2014 |
| Contact name |
William Ward |
| E-mail(s) |
ward.william@epa.gov
|
| Phone |
919-541-2317
|
| Organization name |
United States EPA
|
| Department |
NHEERL
|
| Lab |
ECD
|
| Street address |
109 TW Alexander Dr
|
| City |
Durham |
| State/province |
NC |
| ZIP/Postal code |
27711 |
| Country |
USA |
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| Platforms (1) |
| GPL6101 |
Illumina ratRef-12 v1.0 expression beadchip |
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| Samples (24)
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| Relations |
| BioProject |
PRJNA206022 |
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