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Series GSE47574 Query DataSets for GSE47574
Status Public on Jun 01, 2014
Title Expression data from mouse testis following chronic exposure to acrylamide via the drinking water
Organism Mus musculus
Experiment type Expression profiling by array
Summary Acrylamide is a reproductive toxicant that has been detected in foods such as potato chips and breads. The consequences of chronic exposure to acrylamide in the human diet are unknown; however we previously reported that exposure to acrylamide at levels equivalent to human exposure produced high levels of genetic damage in early male germ cells of mice [Nixon et al. ToxSci 129(1), 135–145 (2012)]. In the present study, we examined changes in testicular gene expression in these mice to examine the potential mechanisms involved in acrylamide induced DNA damage in male germ cells and to provide a better understanding of the reproductive toxic effects of acrylamide in the male.
 
Overall design Adult male mice were subjected to chronic acrylamide exposure via the drinking water at concentrations of 0, 0.001, 0.01, 0.1, 1 and 10 µg/ml for 1, 6 and 12 months. The testes were collected at each time point for RNA extraction and hybridization on an Illumina Sentrix Mouse ref-8 v2 Beadchip.
 
Contributor(s) Nixon BJ, Roman SD
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Submission date May 31, 2013
Last update date Jun 14, 2018
Contact name Belinda Nixon
E-mail(s) belinda.nixon@uon.edu.au
Organization name University of Newcastle
Street address University Drive
City Callaghan
State/province NSW
ZIP/Postal code 2308
Country Australia
 
Platforms (1)
GPL6885 Illumina MouseRef-8 v2.0 expression beadchip
Samples (46)
GSM1152570 Control 1 month rep 1
GSM1152571 Control 1 month rep 2
GSM1152572 Control 1 month rep 3
Relations
BioProject PRJNA206184

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE47574_RAW.tar 3.1 Mb (http)(custom) TAR
GSE47574_non-normalized_data.txt.gz 2.6 Mb (ftp)(http) TXT
Raw data are available on Series record
Processed data included within Sample table

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