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Series GSE47582 Query DataSets for GSE47582
Status Public on Sep 30, 2013
Title miRNA expression in primary renal carcinomas, subgrouped based on HIF1α expression
Platform organism synthetic construct
Sample organism Homo sapiens
Experiment type Non-coding RNA profiling by array
Summary Clear cell renal cell carcinoma (ccRCC), the most common type of renal cancer is often associated with inactivation of the tumor suppressor gene von-Hippel Lindau (VHL), leading to stable expression of hypoxia inducible factors, HIF1α and HIF2α. Although HIF1α functions as a tumor suppressor gene, majority of ccRCCs constitutively express HIF1α, stratifying VHL-deficient ccRCCs into groups which express either both HIF1α and HIF2α (H1H2) or HIF2α exclusively (H2).
MicroRNA (miRNA) profiling performed in these two ccRCC subtypes to identify novel molecular mechanisms.
 
Overall design ccRCCs were classified into H1H2 and H2 subtypes by immunohostochemical staining of H1F1α and H1F2α expression. Five H1H2 tumor samples and eight H2 tumor samples were used for the study. Matched adjacent normal renal tissues were used as respective controls.
 
Contributor(s) Lal P, Simon C
Citation(s) 24189146
Submission date May 31, 2013
Last update date May 02, 2017
Contact name lijoy mathew
E-mail(s) lijoykm@gmail.com
Organization name university of pennsylvania
Lab Celsete Simon
Street address 438 brb II/III, curie blvd
City philadelphia
State/province pa
ZIP/Postal code 19090
Country USA
 
Platforms (1)
GPL8786 [miRNA-1] Affymetrix Multispecies miRNA-1 Array
Samples (26)
GSM1152707 Tumor RCC H2only 3110_12137_1A
GSM1152708 Normal RCC H2only 3110_12138_2B
GSM1152709 Tumor RCC H2only 3110_12139_3A
Relations
BioProject PRJNA206194

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE47582_RAW.tar 4.1 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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