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| Status |
Public on May 31, 2016 |
| Title |
Genome-wide analysis of parental wild-type and derived doxorubicin resistant SK-N-SH neuroblastoma cell lines as well as those co-treated with the histone deacetylase inhibitor SAHA |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Analysis of varied biologic pathways in neuroblastoma SK-N-SH cells grown in doxorubicin and/or SAHA. The hypothesis was that SK-N-SH cells undergo a mesenchymal change through mesenchymal change resulting in a more invasive as well as drug resistant phenotype, and that the mechanism of SAHAs effect on drug resistance may be revealed through this analysis.
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| Overall design |
Total RNA was isolated from wild type, SAHA treated wild type cells, doxorubicin resistant, and SAHA treated doxorubicin resistant SK-N-SH cell lines in triplicate.
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| Contributor(s) |
Naiditch J, Jie C |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Jun 05, 2013 |
| Last update date |
Aug 13, 2018 |
| Contact name |
Chunfa Jie |
| E-mail(s) |
cjie.jhmi@gmail.com
|
| Phone |
3124043831
|
| Organization name |
Des Moines University
|
| Street address |
3200 Grand Ave
|
| City |
Des Moines |
| State/province |
IA |
| ZIP/Postal code |
50266 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL10558 |
Illumina HumanHT-12 V4.0 expression beadchip |
|
| Samples (12)
|
| GSM1154288 |
SK-N-SH-wild type treated with SAHA 1 |
| GSM1154289 |
SK-N-SH-wild type treated with SAHA 2 |
| GSM1154290 |
SK-N-SH-wild type treated with SAHA 3 |
| GSM1154291 |
SK-N-SH-doxorubicin resistant 1 |
| GSM1154292 |
SK-N-SH-doxorubicin resistant 2 |
| GSM1154293 |
SK-N-SH-doxorubicin resistant 3 |
| GSM1154294 |
SK-N-SH-doxorubicin resistant + treated with SAHA 1 |
| GSM1154295 |
SK-N-SH-doxorubicin resistant + treated with SAHA 2 |
| GSM1154296 |
SK-N-SH-doxorubicin resistant + treated with SAHA 3 |
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| This SubSeries is part of SuperSeries: |
| GSE47670 |
Microarray analysis of derived doxorubicin resistant neuroblastoma SK-N-Be(2)C and SK-N-SH cell lines |
|
| Relations |
| BioProject |
PRJNA207087 |
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