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| Status |
Public on Nov 13, 2006 |
| Title |
Genomic aberrations in MMTV-cdc25a;MMTV-neu murine cell line |
| Organism |
Mus musculus |
| Experiment type |
Genome variation profiling by genome tiling array
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| Summary |
CDC25A is a critical target of checkpoint, and its overexpression is observed in various cancers. Here we demonstrate that in vivo levels of Cdc25A expression determine the efficiency of transformation and tumorigenesis. Transgenic expression of CDC25A in murine mammary glands cooperates with tumorigenesis induced by expression of ras or neu. CDC25A- overexpressing tumors display aggressiveness and genomic instability with changes in fragile chromosomal regions, including the region orthologous to human 1p32-36.
Keywords: genetic modification, aCGH
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| Overall design |
Genomic DNA from a MMTV-cdc25a;MMTV-neu double transgenic murine cell line derived from a mammary tumor was compared to normal mammary tissue DNA from the parental strain. A total of two hybridizations were completed.
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| Contributor(s) |
Fuhrken PG, Kiyokawa H, Papoutsakis ET, Ray D |
| Citation(s) |
17283130 |
| Submission date |
May 03, 2006 |
| Last update date |
Feb 06, 2013 |
| Contact name |
Eleftherios Terry Papoutsakis |
| E-mail(s) |
papoutsakis@dbi.udel.edu
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| Organization name |
University of Delaware
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| Department |
Chemical Engineering
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| Street address |
15 Innovation Way
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| City |
Newark |
| State/province |
DE |
| ZIP/Postal code |
19711 |
| Country |
USA |
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| Platforms (1) |
| GPL2884 |
Agilent-013490 Mouse Genome CGH Microarray 44A G4414A (Feature Number version) |
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| Samples (2) |
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| Relations |
| BioProject |
PRJNA95647 |
