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Series GSE47902 Query DataSets for GSE47902
Status Public on Aug 13, 2014
Title Expression profiles of wildtype and SHOX transgenic embryonic mouse limbs
Organism Mus musculus
Experiment type Expression profiling by array
Summary Deficiency of the human short stature homeobox-containing gene (SHOX) has been identified in several disorders characterized by reduced height and skeletal anomalies such as Turner, Leri-Weill and Langer syndrome as well as idiopathic short stature. Although highly conserved in vertebrates, rodents lack a SHOX orthologue.
Here, we compared gene expression profiles of wildtype and SHOX transgenic mouse limbs using microarray experiments to identify SHOX target genes in the developing limb.
Overall design Limbs of E12.5 mouse embryos were dissected, fore- and hindlimbs were pooled and genotyped for RNA extraction. RNA from 2 to 4 littermates was pooled per genotype (Wildtype and SHOX transgene) and compared. In total, 2 microarray hybridization experiments were performed using RNA from 2 biological replicate samples for each genotype.
Contributor(s) Beiser KU, Gretz N
Citation(s) 24887312
Submission date Jun 13, 2013
Last update date Sep 04, 2014
Contact name Carsten Sticht
Organization name University Heidelberg
Department ZMF
Street address Theodor-Kutzer-Ufer
City Mannheim
ZIP/Postal code 68169
Country Germany
Platforms (1)
GPL14661 [Mouse430_2_Mm_EntrezG] Affymetrix GeneChip Mouse Genome 430 2.0 Array [Brainarray Version 13]
Samples (4)
GSM1162177 tg_0909
GSM1162178 wt_0909
GSM1162179 wt_0309
BioProject PRJNA208290

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE47902_RAW.tar 24.5 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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