|
| Status |
Public on Nov 01, 2007 |
| Title |
Novel mechanisms of galactose toxicity in human galactose-1-phosphate uridyltransferase (GALT)-deficient cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Comparison of gene expression profiles in GALT-deficient and GALT-reconstituted cells showed that cells lacking GALT activity responded to galactose challenge by activating a set of genes characteristic of endoplasmic reticulum (ER) stress. This response was specific to galactose insult, as cells grown in glucose or hexose-free media did not exhibit ER stress.
Keywords: GALT infected cells
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| |
|
| Overall design |
Cells were first grown and then infected in high glucose, then transferred to DMEM, 3 experiments with dye-swap
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| |
|
| Contributor(s) |
Lai K, Slepak TI, Slepak VZ |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
May 18, 2006 |
| Last update date |
Dec 06, 2012 |
| Contact name |
Kent Lai |
| E-mail(s) |
klai@med.miami.edu
|
| Organization name |
University of Miami
|
| Department |
Pediatrics
|
| Street address |
P.O. Box 016820
|
| City |
Miami |
| State/province |
FL |
| ZIP/Postal code |
33101 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL1708 |
Agilent-012391 Whole Human Genome Oligo Microarray G4112A (Feature Number version) |
|
| Samples (6)
|
| GSM109331 |
Q188Rfibroblasts_glucose_2days_rep1 |
| GSM109332 |
Q188Rfibroblasts_glucose_2days_rep2 |
| GSM109333 |
Q188Rfibroblasts_hexosefree_2days_rep2 |
| GSM109334 |
Q188Rfibroblasts_hexosefree_2days_rep1 |
| GSM109335 |
Q188Rfibroblasts_galactose_2days_rep1 |
| GSM109336 |
Q188Rfibroblasts_galactose_2days_rep2 |
|
| Relations |
| BioProject |
PRJNA95751 |
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