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Series GSE487 Query DataSets for GSE487
Status Public on Jul 16, 2003
Title PGA Rat Liver Methylprednisolone
Organism Rattus norvegicus
Experiment type Expression profiling by array
Summary Summary: The liver is the major site of gluconeogenesis, fat processing and distribution, as well as drug and xenobiotic metabolism. Altered gene expression in the liver is centrally invovled in both the immuosuppressive and the energetic actions of corticosteroids.

Hypothesis: That pharmacodynamics can be derived from expression profiling data.

Specific Aim: The aim of this project is to identify distinct temporal patters of RNA expression in the liver of rats following a bolus dose of the corticosteroid methylprednisolone. 47 RG_U34A chips were used for 17 time points.
 
 
Contributor(s) Almon R
Citation(s) 12808002, 19787073
Submission date Jul 01, 2003
Last update date Oct 01, 2019
Contact name Eric P Hoffman
E-mail(s) ericphoffman@gmail.com
Organization name Binghamton University - SUNY
Department Pharmaceutical Sciences
Street address PO Box 6000
City Binghamton
State/province NY
ZIP/Postal code 13902
Country USA
 
Platforms (2)
GPL85 [RG_U34A] Affymetrix Rat Genome U34 Array
GPL341 [RAE230A] Affymetrix Rat Expression 230A Array
Samples (91)
GSM4183 PGA-RLM-15m-1aA-s2
GSM4184 PGA-RLM-0.25h-2aA-s2
GSM4185 PGA-RLM-0.25h-3aA-s2
Relations
BioProject PRJNA85181

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE487_RAW.tar 213.9 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file

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