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Status |
Public on Jul 11, 2013 |
Title |
TLR9 deficiency promotes CD73 expression in T cells and diabetes protection in NOD mice |
Organism |
Mus musculus |
Experiment type |
Expression profiling by array
|
Summary |
Analyze the effect of TLR9 deficiency on immue cell function at the gene expression level. Our hypothesis was that TLR9 deficiency promotes CD73 expression in T cells thus regulates autoimmune diabetes development in NOD mice.
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Overall design |
Sorted TCRb+ cells were pooled from several mice for furhter RNA extraction and cRNA labeling.
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Contributor(s) |
Wen L, Wong SF, Tai N |
Citation(s) |
23956420 |
Submission date |
Jul 11, 2013 |
Last update date |
Sep 06, 2013 |
Contact name |
NINGWEN TAI |
Organization name |
Yale University
|
Department |
Internal Medicine
|
Lab |
WEN lab
|
Street address |
300 Cedar Street
|
City |
New Haven |
State/province |
CT |
ZIP/Postal code |
06520 |
Country |
USA |
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Platforms (1) |
GPL6105 |
Illumina mouse-6 v1.1 expression beadchip |
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Samples (2) |
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Relations |
BioProject |
PRJNA211749 |