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| Status |
Public on Jun 30, 2014 |
| Title |
A systems biology approach to understand the pathophysiological mechanisms of cardiac pathological hypertrophy associated with rosiglitazone |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Cardiac pathological hypertrophy is associated with a significantly increased risk of coronary heart disease and has been observed in diabetic patients treated with rosiglitazone, whereas most published studies do not suggest a similar increase in risk of cardiovascular events in pioglitazone-treated diabetic subjects. This study sought to understand the pathophysiological mechanisms underlying the disparate cardiovascular effects of rosiglitazone and pioglitazone and yield knowledge as to the causative nature of rosiglitazone-associated cardiac hypertrophy.
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| Overall design |
Total RNA obtained from mouse Apex from LDLr-/- mice treated with High Fat diet (HF) diet as control (n=6) or HF+Pio (n=5) or HF+Rosi (n=5).
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| Contributor(s) |
Verschuren L, Wielinga PY, Kelder T, Radonjic M, Salic K, Kleemann R, van Ommen B, Kooistra T |
| Citation(s) |
24938300 |
| Submission date |
Jul 17, 2013 |
| Last update date |
Jun 14, 2018 |
| Contact name |
Lars Verschuren |
| E-mail(s) |
lars.verschuren@tno.nl
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| Phone |
+31888666039
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| Organization name |
TNO
|
| Department |
Microbiology and Systems Biology
|
| Street address |
Utrechtseweg 48
|
| City |
Zeist |
| ZIP/Postal code |
3704HE |
| Country |
Netherlands |
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| Platforms (1) |
| GPL6885 |
Illumina MouseRef-8 v2.0 expression beadchip |
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| Samples (16)
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| Relations |
| BioProject |
PRJNA212503 |
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