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Series GSE48977 Query DataSets for GSE48977
Status Public on Jun 30, 2014
Title A systems biology approach to understand the pathophysiological mechanisms of cardiac pathological hypertrophy associated with rosiglitazone
Organism Mus musculus
Experiment type Expression profiling by array
Summary Cardiac pathological hypertrophy is associated with a significantly increased risk of coronary heart disease and has been observed in diabetic patients treated with rosiglitazone, whereas most published studies do not suggest a similar increase in risk of cardiovascular events in pioglitazone-treated diabetic subjects. This study sought to understand the pathophysiological mechanisms underlying the disparate cardiovascular effects of rosiglitazone and pioglitazone and yield knowledge as to the causative nature of rosiglitazone-associated cardiac hypertrophy.
Overall design Total RNA obtained from mouse Apex from LDLr-/- mice treated with High Fat diet (HF) diet as control (n=6) or HF+Pio (n=5) or HF+Rosi (n=5).
Contributor(s) Verschuren L, Wielinga PY, Kelder T, Radonjic M, Salic K, Kleemann R, van Ommen B, Kooistra T
Citation(s) 24938300
Submission date Jul 17, 2013
Last update date Jun 14, 2018
Contact name Lars Verschuren
Phone +31888666039
Organization name TNO
Department Microbiology and Systems Biology
Street address Utrechtseweg 48
City Zeist
ZIP/Postal code 3704HE
Country Netherlands
Platforms (1)
GPL6885 Illumina MouseRef-8 v2.0 expression beadchip
Samples (16)
GSM1191014 HF_Apex_205
GSM1191015 HF_Apex_208
GSM1191016 HF_Apex_209
BioProject PRJNA212503

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE48977_RAW.tar 3.1 Mb (http)(custom) TAR
GSE48977_non-normalized.txt.gz 2.5 Mb (ftp)(http) TXT
Raw data are available on Series record
Processed data included within Sample table

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