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| Status |
Public on May 20, 2014 |
| Title |
Genome-wide map of GATA6 DNA binding in human CRC cells |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
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| Summary |
We describe the genome-wide DNA-binding of GATA6 in a human CRC cell line (LS174T). GATA6 is found to bind the promoter of genes involved in the maintenance of intestinal stem cells, including genes of the Wnt and TGFbeta/BMP pathways. With this we describe a novel GATA6-dependent mechanism of stem cell maintenance in colorectal tumors.
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| Overall design |
Examination of GATA6 binding and H3K4me1, H3K4me3 and H3K27ac levels in a human CRC cell line by Chromatin immunoprecipitation followed by deep sequencing.
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| Contributor(s) |
Martinelli P, Whissel G, Carrillo de Santa Pau E, Vicent GP, Stephan-Otto Attolini C, Real FX, Batlle E |
| Citation(s) |
24952462 |
| Submission date |
Jul 29, 2013 |
| Last update date |
May 15, 2019 |
| Contact name |
Camille Stephan Otto Attolini |
| Organization name |
IRB Barcelona
|
| Department |
Biostatistics and bioinformatics Unit
|
| Street address |
Baldiri Reixac 10
|
| City |
Barcelona |
| State/province |
Select a State or Province |
| ZIP/Postal code |
08028 |
| Country |
Spain |
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| Platforms (2) |
| GPL10999 |
Illumina Genome Analyzer IIx (Homo sapiens) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
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| Samples (7)
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| This SubSeries is part of SuperSeries: |
| GSE56897 |
The transcription factor GATA6 allows self-renewal of colon adenoma stem cells by repressing BMP gene expression |
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| Relations |
| BioProject |
PRJNA213625 |
| SRA |
SRP028302 |
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