|
| Status |
Public on Sep 02, 2014 |
| Title |
Methylation profiling data from medulloblastoma tumor samples |
| Organism |
Homo sapiens |
| Experiment type |
Methylation profiling by genome tiling array
|
| Summary |
Smoothened (SMO)-inhibitors recently entered clinical trials for sonic-hedgehog driven medulloblastoma (SHH-MB). Clinical response appears highly variable. To understand the mechanism(s) of primary resistance and to identify pathways co-operating with aberrant SHH-signaling, we sequenced a large cohort of SHH-MBs across all age groups by sequencing, DNA methylation and expression profiling. Our data show that most adults but only half of the pediatric patients with SHH-MB will respond to SMO inhibition as predicted by molecular analysis of the primary tumor and tested in the SHH-xenografts, demonstrating that the next generation of SMO-inhibitor trials should be based on these predictive biomarkers.
To further dissect the biological differences between the different age groups within SHH medulloblastomas, we looked at the DNA methylation profiles of SHH medulloblastoma samples.
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| |
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| Overall design |
We investigated the DNA methylation profiles of 46 SHH medulloblastomas across all age groups using the Illumina 450k methylation array.
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| |
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| Contributor(s) |
Remke M, Cavalli FM, Hovestadt V, Kool M, Pfister SM, Taylor MD |
| Citation(s) |
24651015 |
| Submission date |
Jul 30, 2013 |
| Last update date |
Mar 22, 2019 |
| Contact name |
Marc Remke |
| E-mail(s) |
marcremke@gmail.com
|
| Organization name |
The Hospital for Sick Children
|
| Department |
Laboratory Medicine and Pathobiology
|
| Street address |
555 University Ave. Rm 1504
|
| City |
Toronto |
| ZIP/Postal code |
M5G 1X8 |
| Country |
Canada |
| |
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| Platforms (1) |
| GPL13534 |
Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482) |
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| Samples (46)
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| Relations |
| BioProject |
PRJNA213744 |
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