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Series GSE4959 Query DataSets for GSE4959
Status Public on Jun 03, 2006
Title Expression data from adult Rattus liver
Organism Rattus norvegicus
Experiment type Expression profiling by array
Summary Activation of the pregnane X receptor (NR1I2) by drugs and other xenobiotics stimulates (or suppresses) expression of numerous genes involved in the metabolic elimination of foreign compounds and some toxic endogenous substrates.
We used microarray analysis to identify genes whose expression in rat liver was significantly altered by pregnenolone 16alpha-carbonitrile (PCN) treatment.
Keywords: a single ip injection of PCN (100 mg/kg), 8 h treatment
Overall design We chose to profile the gene expression pattern in the livers of adult rats to test the idea that PCN counteracts a wide variety of stresses by activating genes apart from drug metabolism.
Contributor(s) Guzelian J, Barwick JL, Hunter L, Phang TL, Quattrochi LC, Guzelian PS
Citation(s) 16997903
Submission date May 31, 2006
Last update date Mar 03, 2017
Contact name Linda C Quattrochi
Phone 303-315-3522
Organization name University of Colorado at Denver and Health Sciences
Department Medicine
Lab Quattrochi
Street address 4200 E. 9th Ave, B146
City Denver
State/province CO
ZIP/Postal code 80262
Country USA
Platforms (2)
GPL341 [RAE230A] Affymetrix Rat Expression 230A Array
GPL342 [RAE230B] Affymetrix Rat Expression 230B Array
Samples (19)
GSM111888 corn oil control, biological rep1a
GSM111889 corn oil control, biological rep1b
GSM111890 corn oil control, biological rep2a
BioProject PRJNA96711

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