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| Status |
Public on Jul 24, 2014 |
| Title |
Regulatory consequences of TARBP2 knock-down in MDA-LM2 cell-line [stability experiment] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
siRNA-mediated knock-down followed by transcriptomic profiling revealed that silencing of TARBP2 resulted in a significant increase in the stability of sRSE-carrying transcripts.
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| |
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| Overall design |
Two independent siRNAs were used to knock down TARBP2 in metastatic MDA-LM2 cells. The cells were then subjected to whole-genome transcript stabiliy measurements in comparison to mock-transfected cells.
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| |
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| Contributor(s) |
Goodarzi H, Zhang S, Buss CG, Fish L, Tavazoie S, Tavazoie SF |
| Citation(s) |
25043050 |
| Submission date |
Aug 07, 2013 |
| Last update date |
Aug 13, 2018 |
| Contact name |
Hani Goodarzi |
| Organization name |
UCSF
|
| Department |
Biochemistry and Biophysics
|
| Street address |
600 16th St, GH S312D
|
| City |
San Francisco |
| State/province |
CA |
| ZIP/Postal code |
94158 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL10558 |
Illumina HumanHT-12 V4.0 expression beadchip |
|
| Samples (8)
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| This SubSeries is part of SuperSeries: |
| GSE49649 |
Metastasis-suppressor transcript destabilization through TARBP2 binding of mRNA hairpins |
|
| Relations |
| BioProject |
PRJNA214604 |
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