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Series GSE49968 Query DataSets for GSE49968
Status Public on Mar 27, 2014
Title The Menin-Bach2 axis is critical for regulating CD4 T cell senescence and cytokine homeostasis
Organism Mus musculus
Experiment type Expression profiling by array
Summary Although CD4 T cell senescence plays an important role in immunosenescence, the mechanism behind this process remains unclear. Here we show that T cell-specific Menin deficiency results in the premature senescence of CD4 T cells, which is accompanied by the senescence-associated secretory phenotype after antigenic stimulation and dysregulated cytokine production. Menin is required for the expansion and survival of antigen-stimulated CD4 T cells in vivo and acts by targeting Bach2, which is known to regulate immune homeostasis and cytokine production. Menin binds to the Bach2 locus, and controls its expression through maintenance of histone acetylation. Menin binding at the Bach2 locus and the Bach2 expression are decreased in the senescent CD4 T cells. These findings reveal a critical role of the Menin-Bach2 pathway in regulating CD4 T cell senescence and cytokine homeostasis, thus indicating the involvement of this pathway in the inhibition of immunosenescence.
 
Overall design Gene expression in Menin WT-TH and Menin KO-TH
 
Contributor(s) Kuwahara M, Suzuki J, Tofukuji S, Yamada T, Kanoh M, Matsumoto A, Maruyama S, Kometani K, Kurosaki T, Ohara O, Nakayama T, Yamashita M
Citation(s) 24694524
Submission date Aug 19, 2013
Last update date Jan 12, 2017
Contact name Makoto Kuwahara
E-mail(s) mkuwa@m.ehime-u.ac.jp
Organization name Graduate School of Medicine, Ehime University
Department Department of Immunology
Lab Immunology
Street address Shitsukawa
City Toon-shi
State/province Ehime
ZIP/Postal code 791-0295
Country Japan
 
Platforms (1)
GPL7202 Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Probe Name version)
Samples (2)
GSM1210931 Menin_WT_TH
GSM1210932 Menin_KO_TH
Relations
BioProject PRJNA215716

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE49968_RAW.tar 4.4 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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