|
|
GEO help: Mouse over screen elements for information. |
|
Status |
Public on Aug 27, 2013 |
Title |
Effect of adiponectin deficiency on pulmonary responses to subacute ozone exposure in mice |
Organism |
Mus musculus |
Experiment type |
Expression profiling by array
|
Summary |
Adiponectin is an adipose-derived hormone with anti-inflammatory activity. Following subacute ozone exposure (0.3 ppm for 24-72 h), pulmonary neutrophilic inflammation is augmented in adiponectin deficient mice. The purpose of this study was to use microarrays to examine the impact of adiponectin deficiency on changes in pulmonary gene expression induced by ozone, a common air pollutant.
|
|
|
Overall design |
Lungs were harvested from wildtype and mice that were genetically deficient in adiponectin. Mice were exposed either to room air or to ozone (0.3 ppm) for 72 h. RNA was extracted and microarray analysis of gene expression performed. Both male and female mice were used.
|
|
|
Contributor(s) |
Shore SA, Kasahara DI |
Citation(s) |
24381131 |
Submission date |
Aug 26, 2013 |
Last update date |
May 04, 2018 |
Contact name |
Stephanie A Shore |
E-mail(s) |
sshore@hsph.harvard.edu
|
Organization name |
Harvard School of Public Health
|
Department |
Environmental Health
|
Lab |
Shore Lab
|
Street address |
665 Huntigton Av Bld1 room 307
|
City |
Boston |
State/province |
MA |
ZIP/Postal code |
02115 |
Country |
USA |
|
|
Platforms (1) |
GPL8321 |
[Mouse430A_2] Affymetrix Mouse Genome 430A 2.0 Array |
|
Samples (16)
|
GSM1215202 |
whole lung RNA, wildtype mouse, air exposed, male replicate 1 |
GSM1215203 |
whole lung RNA, wildtype mouse, air exposed, male replicate 2 |
GSM1215204 |
whole lung RNA, wildtype mouse, air exposed, female replicate 1 |
GSM1215205 |
whole lung RNA, wildtype mouse, air exposed, female replicate 2 |
GSM1215206 |
whole lung RNA, adiponectin deficient mouse, air exposed, male replicate 1 |
GSM1215207 |
whole lung RNA, adiponectin deficient mouse, air exposed, male replicate 2 |
GSM1215208 |
whole lung RNA, adiponectin deficient mouse, air exposed, female replicate 1 |
GSM1215209 |
whole lung RNA, adiponectin deficient mouse, air exposed, female replicate 2 |
GSM1215210 |
whole lung RNA, wildtype mouse, ozone exposed, male replicate 1 |
GSM1215211 |
whole lung RNA, wildtype mouse, ozone exposed, male replicate 2 |
GSM1215212 |
whole lung RNA, wildtype mouse, ozone exposed, female replicate 1 |
GSM1215213 |
whole lung RNA, wildtype mouse, ozone exposed, female replicate 2 |
GSM1215214 |
whole lung RNA, adiponectin deficient mouse, ozone exposed, male replicate 1 |
GSM1215215 |
whole lung RNA, adiponectin deficient mouse, ozone exposed, male replicate 2 |
GSM1215216 |
whole lung RNA, adiponectin deficient mouse, ozone exposed, female replicate 1 |
GSM1215217 |
whole lung RNA, adiponectin deficient mouse, ozone exposed, female replicate 2 |
|
Relations |
BioProject |
PRJNA216989 |
Supplementary file |
Size |
Download |
File type/resource |
GSE50183_RAW.tar |
33.5 Mb |
(http)(custom) |
TAR (of CEL) |
Processed data included within Sample table |
|
|
|
|
|