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| Status |
Public on Aug 29, 2013 |
| Title |
The organizational effects of testosterone on brain DNA methylome |
| Organism |
Mus musculus domesticus |
| Experiment type |
Methylation profiling by high throughput sequencing
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| Summary |
Analysis of DNA methylation in the bed nucleus of the stria terminalis/preoptic area and striatum in response to perinatal testosterone exposure. The hypothesis tested was that treatment of females with testosterone on the day of birth would lead to masculinization of the methylome in adulthood.
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| Overall design |
There were three experimental groups: males, females, and females treated with T on the day of birth. The methylation patterns in each group was determined using reduced representation bisulfite sequencing. Two brain regions and two time points (day 4 and day 60) were surveyed in each group. Each biological replicate is a pool of tissue from three animals.
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| Contributor(s) |
Ghahramani NM, Ngun TC, Chen P, Tian Y, Krishnan S, Muir S, Rubbi L, Arnold AP, de Vries GJ, Forger NG, Pellegrini M, Vilain E |
| Citation(s) |
24976947 |
| Submission date |
Aug 27, 2013 |
| Last update date |
May 15, 2019 |
| Contact name |
Pao-Yang Chen |
| Organization name |
Academia Sinica
|
| Department |
Institute of Plant and Microbial Biology
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| Lab |
Pao-Yang Chen
|
| Street address |
128 Sec. 2, Academia Rd, Nankang
|
| City |
Taipei |
| State/province |
Taiwan |
| ZIP/Postal code |
11529 |
| Country |
Taiwan |
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| Platforms (1) |
| GPL17637 |
Illumina HiSeq 2000 (Mus musculus domesticus) |
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| Samples (24)
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| Relations |
| BioProject |
PRJNA217308 |
| SRA |
SRP029250 |
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