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Series GSE50378 Query DataSets for GSE50378
Status Public on Mar 06, 2014
Title Expression data of HUVEC cells after PPARβ/δ agonist and/or hypoxia treatment
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Recently the role of PPARβ/δ in angiogenesis has been revealed, and we hypothesized that the crosstalk between hypoxia and PPARβ/δ on endothelial cells may exsist. To elucidate the interaction between two signalings, we report the comprehensive change of transcripts induced by PPARβ/δ agonist (GW501516) and/or hypoxia.
We used microarray analysis of HUVECs treated with PPARβ/δ agonist (GW501516) and/or hypoxia (1% O2) for 24-hours, and we identified a group of consistently up- or down-regulated genes.
Overall design HUVECs were used within the first 6 passages. HUVECs were treated with PPARβ/δ agonist (GW501516) at a concentration of 100 nM and/or hypoxia (1% O2) for 24-hours. Same concentration of DMSO was used as a control sample, and as to the oxgen, normoxia was used as a control condition.
Contributor(s) Inoue T, Kohro T, Wada Y, Taguchi A, Yamamoto S, Kodama T
Citation(s) 24721177
Submission date Aug 27, 2013
Last update date Mar 25, 2019
Contact name Tsuyoshi Inoue
Organization name The University of Tokyo
Street address Hongo
City Tokyo
ZIP/Postal code 113-8655
Country Japan
Platforms (1)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (4)
GSM1217731 HUVEC_PPARD_hypoxia_DMSO
GSM1217732 HUVEC_PPARD_normoxia_DMSO
GSM1217733 HUVEC_PPARD_hypoxia_PPARDagonist
BioProject PRJNA217364

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE50378_RAW.tar 32.1 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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