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| Status |
Public on Sep 11, 2013 |
| Title |
microRNA profiling of lung adenocarcinomas, induced by cRaf overexpression in lung epithelium (Affymetrix) |
| Platform organism |
synthetic construct |
| Sample organism |
Mus musculus |
| Experiment type |
Non-coding RNA profiling by array
|
| Summary |
In this study we analyzed the expression of miRNAs in the lungs of SP-C/c-raf transgenic mice. The transgene is under the transcriptional control of the surfactant protein C (SP-C) promoter and consists of the oncogenically activated NH2-terminal deletion mutant c-Raf-1-BxB.
Overall this study aims at identifying miRNAs regulated in precursor lesions of lung cancer.
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| Overall design |
Affymetrix platform was used to analyze and compare the miRNA expression pattern in RNA extracts derived from two different conditions, i.e. lung of wild type mice and lung of SP-C/c-raf mice expressing the c-Raf-1 transgene. Each gender and condition was tested separately using 6 different individuals from each group: male and female wild type mice (M WT and F WT) and male and female transgenic mice (M c-Raf and F c-Raf).
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| |
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| Contributor(s) |
Del Vescovo V, Meier T |
| Citation(s) |
24265725 |
| Submission date |
Sep 10, 2013 |
| Last update date |
May 02, 2017 |
| Contact name |
Valerio Del Vescovo |
| E-mail(s) |
valerio@science.unitn.it
|
| Organization name |
University of Trento
|
| Department |
CIBIO - Centre for Integrative Biology
|
| Lab |
RNA Biology and Biotechnology
|
| Street address |
via delle Regole 101
|
| City |
Trento |
| State/province |
Trentino Alto Adige |
| ZIP/Postal code |
38123 |
| Country |
Italy |
| |
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| Platforms (1) |
| GPL8786 |
[miRNA-1] Affymetrix Multispecies miRNA-1 Array |
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| Samples (18)
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| This SubSeries is part of SuperSeries: |
| GSE50753 |
microRNA profiling of lung adenocarcinomas, induced by cRaf overexpression in lung epithelium |
|
| Relations |
| BioProject |
PRJNA218797 |
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