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Status |
Public on Feb 18, 2016 |
Title |
Comparative transcriptome profiling of the injured zebrafish and mouse hearts identifies miRNA-dependent repair pathways |
Organism |
Danio rerio |
Experiment type |
Expression profiling by array
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Summary |
The mammalian heart has poor regenerative capacity following injury. In contrast, certain lower vertebrates such as zebrafish retain a robust capacity for regeneration into adult life. Here we use an integrated approach to identify evolutionary conserved regenerative miRNA-dependant regulatory circuits in the heart. We identified novel miRNA-dependant networks involved in critical biological pathways, which are differentially utilized between the infarcted mouse heart and the regenerating zebrafish heart.
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Overall design |
2 conditions, 4 biological replicates per condition
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Contributor(s) |
Crippa S, Ounzain S, Ibberson M, Nemir M, Berthonneche C, Sarre A, Boisset G, Harshman K, Xenarios I, Diviani D, Schorderet D, Pedrazzini T |
Citation(s) |
26857418 |
Submission date |
Sep 19, 2013 |
Last update date |
Jan 25, 2018 |
Contact name |
Mark Ibberson |
Organization name |
SIB Swiss Institute of Bioinformatics
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Department |
Vital-IT
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Street address |
Genopode building
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City |
Lausanne |
ZIP/Postal code |
CH-1015 |
Country |
Switzerland |
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Platforms (1) |
GPL1319 |
[Zebrafish] Affymetrix Zebrafish Genome Array |
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Samples (8)
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GSM1234850 |
Heart, Control, rep4 |
GSM1234851 |
Heart, Resected, rep1 |
GSM1234852 |
Heart, Resected, rep2 |
GSM1234853 |
Heart, Resected, rep3 |
GSM1234854 |
Heart, Resected, rep4 |
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This SubSeries is part of SuperSeries: |
GSE51014 |
Comparative transcriptome profiling of the injured zebrafish and mouse hearts identifies miRNA-dependent repair pathways |
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Relations |
BioProject |
PRJNA219633 |
Supplementary file |
Size |
Download |
File type/resource |
GSE51013_RAW.tar |
14.9 Mb |
(http)(custom) |
TAR (of CEL) |
Processed data included within Sample table |
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