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| Status |
Public on Feb 18, 2016 |
| Title |
Comparative transcriptome profiling of the injured zebrafish and mouse hearts identifies miRNA-dependent repair pathways |
| Organism |
Mus musculus |
| Experiment type |
Non-coding RNA profiling by high throughput sequencing
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| Summary |
The mammalian heart has poor regenerative capacity following injury. In contrast, certain lower vertebrates such as zebrafish retain a robust capacity for regeneration into adult life. Here we use an integrated approach to identify evolutionary conserved regenerative miRNA-dependant regulatory circuits in the heart. We identified novel miRNA-dependant networks involved in critical biological pathways, which are differentially utilized between the infarcted mouse heart and the regenerating zebrafish heart.
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| Overall design |
2 conditions, 3 biological replicates per condition
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| Contributor(s) |
Crippa S, Ounzain S, Ibberson M, Nemir M, Berthonneche C, Sarre A, Boisset G, Harshman K, Xenarios I, Diviani D, Schorderet D, Pedrazzini T |
| Citation(s) |
26857418 |
| Submission date |
Sep 19, 2013 |
| Last update date |
May 15, 2019 |
| Contact name |
Mark Ibberson |
| Organization name |
SIB Swiss Institute of Bioinformatics
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| Department |
Vital-IT
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| Street address |
Genopode building
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| City |
Lausanne |
| ZIP/Postal code |
CH-1015 |
| Country |
Switzerland |
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| Platforms (1) |
| GPL9250 |
Illumina Genome Analyzer II (Mus musculus) |
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| Samples (6)
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| This SubSeries is part of SuperSeries: |
| GSE51014 |
Comparative transcriptome profiling of the injured zebrafish and mouse hearts identifies miRNA-dependent repair pathways |
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| Relations |
| BioProject |
PRJNA219640 |
| SRA |
SRP030037 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE51019_mouse_mirna_normalized.txt.gz |
17.2 Kb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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