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| Status |
Public on Jun 22, 2006 |
| Title |
Expression data from MOLT4 human cell line |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
To compare The pattern of Gene expression by 7-hydroxymethotrexate-resistant human leukemia cells reveals changes designed to preserve intracellular levels of folate and nucleotide biosynthesis
We used microarrays to detail the global programme of gene expression underlying cellularisation and identified distinct classes of up-regulated genes during this process.
Keywords: Resistant and non-resistant MOLT4 cell lines
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| Overall design |
Treatment of human T-cell leukemia lines to the major plasma metabolite of methotrexate (MTX), 7-hydroxymethotrexate (7-OHMTX), resulted in an acquired resistance as a results of complete loss of folypolyglutamate synthetase (FPGS) activity. To identify the genes associated with MTX and 7-OHMTX resistance, we analyzed the patterns of gene expression profiles by leukemia sublines and compared with parent cells.
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| Contributor(s) |
Fotoohi K, Moshfegh A, Albertioni F |
| Citation missing |
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| Submission date |
Jun 21, 2006 |
| Last update date |
Aug 10, 2018 |
| Contact name |
Ali Moshfegh |
| E-mail(s) |
ali.moshfegh@ki.se
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| Organization name |
Karolinska Institutet
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| Department |
Oncology and Pathology
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| Street address |
Z5:01
|
| City |
Stockholm |
| ZIP/Postal code |
17176 |
| Country |
Sweden |
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| Platforms (1) |
| GPL96 |
[HG-U133A] Affymetrix Human Genome U133A Array |
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| Samples (9)
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| Relations |
| BioProject |
PRJNA96613 |
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