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Series GSE51188 Query DataSets for GSE51188
Status Public on Sep 27, 2013
Title The Stress-Regulated Transcription Factor CHOP Promotes Hepatic Inflammatory Gene Expression, Fibrosis, and Oncogenesis
Organism Mus musculus
Experiment type Expression profiling by array
Summary Viral hepatitis, obesity, and alcoholism all represent major risk factors for hepatocellular carcinoma (HCC). Although these conditions also lead to integrated stress response (ISR) or unfolded protein response (UPR) activation, the extent to which these stress pathways influence the pathogenesis of HCC has not been tested. Here we provide multiple lines of evidence demonstrating that the ISR-regulated transcription factor CHOP promotes liver cancer. We show that CHOP expression is upregulated in liver tumors in human HCC and two mouse models thereof. Chop-null mice are resistant to chemical hepatocarcinogenesis, and these mice exhibit attenuation of both apoptosis and cellular proliferation. Chop-null mice are also resistant to fibrosis, which is a key risk factor for HCC. Global gene expression profiling suggests that deletion of CHOP reduces the levels of basal inflammatory signaling in the liver. Our results are consistent with a model whereby CHOP contributes to hepatic carcinogenesis by promoting inflammation, fibrosis, cell death, and compensatory proliferation. They implicate CHOP as a common contributing factor in the development of HCC in a variety of chronic liver diseases.
 
Overall design 24 samples were analyzed from 9 month old male C57BL/6J or backcrossed Chop-/- male mice, injected with either PBS or a single dose of 25 mg/kg diethylnitrosamine (DEN) at 15 d.o. Samples are either from whole liver or liver tumors.
 
Contributor(s) Rutkowski DT
Citation(s) 24367269
Submission date Sep 26, 2013
Last update date Aug 22, 2019
Contact name David Thomas Rutkowski
E-mail(s) thomas-rutkowski@uiowa.edu
Organization name University of Iowa Carver College of Medicine
Department Anatomy and Cell Biology
Street address 51 Newton Rd.
City Iowa City
State/province IA
ZIP/Postal code 52242
Country USA
 
Platforms (1)
GPL6885 Illumina MouseRef-8 v2.0 expression beadchip
Samples (24)
GSM1240332 wild-type PBS #1
GSM1240333 wild-type DEN #1
GSM1240334 wild-type DEN #2
Relations
BioProject PRJNA221566

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE51188_RAW.tar 3.1 Mb (http)(custom) TAR
GSE51188_non-normalized.txt.gz 7.3 Mb (ftp)(http) TXT
Processed data included within Sample table
Raw data are available on Series record

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