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| Status |
Public on Jan 01, 2014 |
| Title |
Glomerulonephritis in BXSB/MpJ-Yaa mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Analysis of glomeruli isolated from kidneys of 4 month male BXSB/MpJ-Yaa. The BXSB/MpJ-Yaa mouse strain is a lupus-prone model. Results provide insight into the pathogenic mechanisms linked to glomerulonephritis in BXSB/MpJ-Yaa mice.
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| Overall design |
The glomeruli were isolated from 6 BXSB/MpJ-Yaa (glomerulonephritis model) and BXSB/MpJ-Yaa+ (control). 6 glomerular populations of each strain were devided into 3 groups (1 group / 2 populations). 3 glomerulonephritis models versus 3 controls analysis was performed.
BXSB/MpJ-Yaa is a recombinant inbred strain developed originally from a C57BL/6 female mouse and a SB/Le male mouse. Yaa (Y-linked autoimmune accelerator locus) localizing on the Y chromosome of BXSB/MpJ-Yaa male mice is the result of a duplication of an about 4 Mbp telomeric segment near the pseudoautosomal region of the X chromosome onto the Y chromosome. BXSB/MpJ-Yaa+ (control) male mice carry the wild-type Y chromosome in place of the mutant Yaa-containing Y chromosome of BXSB/MpJ-Yaa male mice.
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| Contributor(s) |
Kimura J, Ichii O |
| Citation(s) |
24477164 |
| Submission date |
Sep 27, 2013 |
| Last update date |
Feb 02, 2018 |
| Contact name |
Junpei Kimura |
| E-mail(s) |
kimura-jf@vetmed.hokudai.ac.jp
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| Organization name |
Graduate School of Veterinary Medicine, Hokkaido University
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| Department |
Department of Biomedical Sciences
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| Lab |
Laboratory of Anatomy
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| Street address |
Kita 18-Nishi 9, Kita-ku
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| City |
Sapporo |
| ZIP/Postal code |
060-0818 |
| Country |
Japan |
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| Platforms (1) |
| GPL10787 |
Agilent-028005 SurePrint G3 Mouse GE 8x60K Microarray (Probe Name version) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA221777 |
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