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Series GSE5131 Query DataSets for GSE5131
Status Public on Jul 07, 2006
Title Adjudin-induced germ cell loss from adult rat testes
Organism Rattus norvegicus
Experiment type Expression profiling by array
Summary This is a study to explore the transcriptional changes after Adjudin treatment in adult rat testes at three time points (control, 8 hour and 4 day). Adjudin, [1-(2,4-dichlorobenzyl)-1H-indazole-3-carbohydrazide], is a potential male contraceptive that targets the Sertoli-germ cell interface and causes germ cell depletion from the seminiferous epithelium. Adjudin has been proved to be a useful model to study the mechanisms that regulate junction restructuring in the testis.
Keywords: Sertoli-germ cell adhesion regulation using an Adjudin model
 
Overall design Sprague-Dawley rats treated with a single dose of Adjudin at 50 mg/kg b.w. by gavage and terminated after 8 hours (n=2) and 4 days (n=3). Testes from Adjudin-treated rats and untreated (control, n=3) rats were harvested and total RNA were prepared. Standard Affymetrix genechip procedures were followed for the subsequent experiments. Data were analysed in MAS 5.0 and GeneSpring 7.2.
 
Contributor(s) Xia W, Mruk DD, Lee WM, Cheng Y
Citation(s) 17332525
Submission date Jun 22, 2006
Last update date Jul 31, 2017
Contact name Weiliang Xia
E-mail(s) wxia@mail.rockefeller.edu
Phone 212-327-8738
Fax 212-327-8733
Organization name Population Council
Street address 1230 York Avenue
City New York
State/province NY
ZIP/Postal code 10021
Country USA
 
Platforms (1)
GPL1355 [Rat230_2] Affymetrix Rat Genome 230 2.0 Array
Samples (8)
GSM115949 Adult rat testis-normal 1
GSM115950 Adult rat testis-normal 2
GSM115951 Adult rat testis-normal 3
Relations
BioProject PRJNA96637

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Supplementary file Size Download File type/resource
GSE5131_RAW.tar 35.1 Mb (http)(custom) TAR (of CEL, EXP)
Raw data provided as supplementary file
Processed data included within Sample table

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