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Series GSE5140 Query DataSets for GSE5140
Status Public on Jun 13, 2007
Title Creatine increases health and life span in mice
Organism Mus musculus
Experiment type Expression profiling by array
Summary Here we show that oral creatine (Cr) supplementation leads to increased life span in mice. Treated mice showed improved neurobehavioral performance, decreased accumulation of the aging pigment lipofuscin and upregulation of “anti-aging” genes in brain. As Cr is virtually free of adverse effects, it may be a promising food supplement for healthy aging in man.
Keywords: creatine, life span, neurobehavioural performance, microarray, oxidative stress, aging
 
Overall design 6 biological replicates for creatine-treated mice, 7 biological replicates for untreated mice.
 
Contributor(s) Klopstock T, Bender A, Beckers J, Hölter SM, Haack T, Ruthsatz T, Vogt Weisenhorn DM, Becker L, Genius J, Rujescu D, Irmler M, Mijalski T, Mader M, Quintanilla-Martinez L, Fuchs H, Gailus-Durner V, Hrabé de Angelis M, Wurst W, Schmidt J, Schneider I
Citation(s) 17416441
Submission date Jun 23, 2006
Last update date Feb 11, 2019
Contact name Johannes Beckers
E-mail(s) beckers@helmholtz-muenchen.de
Organization name Helmholtz Zentrum Muenchen
Department Institute of Experimental Genetics
Street address Ingolstaedter Landstr. 1
City Neuherberg
ZIP/Postal code 85764
Country Germany
 
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (13)
GSM115526 Creatine-treated, biological rep1
GSM115527 Creatine-treated, biological rep2
GSM115528 Creatine-treated, biological rep3
Relations
BioProject PRJNA96651

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE5140_RAW.tar 77.3 Mb (http)(custom) TAR (of CEL, XML)
Raw data provided as supplementary file
Processed data included within Sample table

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