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Series GSE51405 Query DataSets for GSE51405
Status Public on Jan 09, 2014
Title Interferon Signature in the Blood in Inflammatory Common Variable Immune Deficiency [Training Set]
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Transcriptional profiling was used to characterize the immunologic networks in subjects with CVID who have inflammatory complications to identify clues as to pathogenesis and potentially better modes of treatment.
 
Overall design CVID subjects who fulfilled the standard diagnostic criteria, including significantly decreased levels of IgG, IgA, and/or IgM and poor or absent specific antibody production were enrolled. They were classified into, with or without characteristic inflammatory complications, as previously designated (hematologic or organ-specific autoimmunity, biopsy-proven granulomatous disease, or interstitial lung disease, lymphoid hyperplasia/ with splenomegaly or gastrointestinal inflammatory disease). 59 patients were included in the training set and 21 healthy controls and for test set 32 patients and 15 healthy controls. Disease controls included 6 X-linked agammaglobulinemia (XLA) patients and 15 healthy controls were included. Blood was taken before the interval intravenous immune globulin (Ig) infusions, or between subcutaneous administrations. The blood was collected using Tempus tubes and processed for microarray analysis.
 
Contributor(s) Park J, Munagala I, Xu H, Blankenship D, Maffucci P, Chaussabel D, Banchereau J, Pascual V, Cunningham-Rundles C
Citation(s) 24069364
Submission date Oct 18, 2013
Last update date Aug 16, 2018
Contact name Indira Munagala
E-mail(s) indira.munagala@baylorhealth.edu
Organization name Baylor healthcare
Department BIIR
Street address 3434 Live Oak street
City Dallas
State/province TX
ZIP/Postal code 75204
Country USA
 
Platforms (1)
GPL6947 Illumina HumanHT-12 V3.0 expression beadchip
Samples (83)
GSM1244876 MR 73_Control-HC
GSM1244877 SV 60_Control-HC
GSM1244878 CM 79_Control-HC
This SubSeries is part of SuperSeries:
GSE51406 Interferon Signature in the Blood in Inflammatory Common Variable Immune Deficiency
Relations
BioProject PRJNA222981

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE51405_RAW.tar 6.2 Mb (http)(custom) TAR
GSE51405_non-normalized_CVID_TRN.txt.gz 27.0 Mb (ftp)(http) TXT
Processed data included within Sample table

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