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| Status |
Public on Jan 02, 2014 |
| Title |
ROR1 Can Interact With TCL1 And Enhance Leukemogenesis in Eµ-TCL1 Transgenic Mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Transcriptome analysis of RNA samples from leukemia cells of ROR1xTCL1 and TCL1 transgenic mice
Animals engrafted with ROR1xTCL1 leukemia-cells developed more aggressive disease than mice engrafted with TCL1 leukemia cells. Transcriptome analysis of RNA samples from leukemia ROR1xTCL1 transgenic mice revealed shared common gene expression signatures that were distinct from those of TCL1 leukemia-cells.
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| Overall design |
We performed microarray transcriptome analyses on isolated leukemia cells that developed in ROR1xTCL1 Tg mice (n=4) or TCL1 Tg mice (n=4) using the Affymetrix Mouse Exon 1.0 ST platform. Array data was processed by Affymetrix Exon Array Computational Tool. No techinical replicates were performed.
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| Contributor(s) |
Widhopf II GF, Cui B, Ghia EM, Chen L, Messer K, Shen Z, Briggs S, Croce CM, Kipps TJ |
| Citation(s) |
24379361 |
| Submission date |
Oct 18, 2013 |
| Last update date |
Mar 03, 2017 |
| Contact name |
Emanuela Maria Ghia |
| E-mail(s) |
eghia@health.ucsd.edu
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| Organization name |
University of California San Diego
|
| Department |
Center For Novel Therapeutics
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| Street address |
9310 Athena Circle
|
| City |
La Jolla |
| State/province |
CA |
| ZIP/Postal code |
92037 |
| Country |
USA |
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| Platforms (1) |
| GPL6193 |
[MoEx-1_0-st] Affymetrix Mouse Exon 1.0 ST Array [probe set (exon) version] |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA223158 |
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