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Series GSE51498 Query DataSets for GSE51498
Status Public on Sep 19, 2015
Title Regulation of HSF1-mediated transcriptional programs by PGC-1alpha
Organisms Homo sapiens; Mus musculus
Experiment type Expression profiling by array
Summary We examined global gene expression patterns in response to PGC-1 expression in cells derived from liver or muscle.
As our study revealed regulation of HSF1 by PGC-1alpha, in some experiments we knocked-down HSF1 using siRNAs in addition to inducing PGC-1alpha expression.
Overall design Cells were grown in 24-well plates and adenoviruses encoding either GFP ("Ad-GFP"), PGC-1alpha ("Ad-PGC-1alpha") or PGC-1beta ("Ad-PGC-1beta") were directly added to the culture medium. For experiments involving siRNA transfections, cells were transfected with the indicated siRNAs 48hr prior to infection with adenoviruses encoding either GFP ("Ad-GFP") or PGC-1alpha ("Ad-PGC-1alpha").
Contributor(s) Minsky N, Roeder RG
Citation(s) 26438876
Submission date Oct 21, 2013
Last update date Mar 04, 2019
Contact name Neri Minsky
Organization name Rockefeller University
Lab Laboratory of Biochemistry and Molecular Biology
Street address 1230 York Avenue
City New York
State/province NY
ZIP/Postal code 10065
Country USA
Platforms (2)
GPL6244 [HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version]
GPL6246 [MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version]
Samples (19)
GSM1246575 Human primary hepatocytes donor 1 infected with Ad-GFP
GSM1246576 Human primary hepatocytes donor 2 infected with Ad-GFP
GSM1246577 Human primary hepatocytes donor 3 infected with Ad-GFP
BioProject PRJNA223320

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE51498_RAW.tar 86.3 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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