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Series GSE51541 Query DataSets for GSE51541
Status Public on Mar 01, 2014
Title Autophagy is essential for cardiac morphogenesis during vertebrate development
Organism Danio rerio
Experiment type Expression profiling by array
Summary This study examined the effects of genetic knockdown of autophagy genes on vertebrate cardiac development
We performed microarray studies comparing the hearts of control zebrafish embryos to the hearts of embryos with decreased expression of the autophagy genes atg5, becn1 or atg7. The results provide insight into the role of autophagy in developmental morphogenesis.
Overall design Hearts were purified from 3 day-old zebrafish embryos injected with control or autophagy gene-specific morpholino oligonucleotides. RNA was prepared from all samples and hybridized to zebrafish-specific Affymetricx arrays.
Contributor(s) Lee E, Ng A, Xavier R, Levine B, Amatruda JF
Citation(s) 24441423
Submission date Oct 22, 2013
Last update date Jan 25, 2018
Contact name James F Amatruda
Phone 214-648-3896
Organization name University of Texas Southwestern Medical Center
Department Pediatrics and Molecular Biology
Street address 5323 Harry Hines Boulevard
City Dallas
State/province TX
ZIP/Postal code 75390-8534
Country USA
Platforms (1)
GPL1319 [Zebrafish] Affymetrix Zebrafish Genome Array
Samples (13)
GSM1247632 Uninjected control biological replicate 1
GSM1247633 Uninjected control biological replicate 2
GSM1247634 Uninjected control biological replicate 3
BioProject PRJNA223395

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE51541_RAW.tar 24.3 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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