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Series GSE51615 Query DataSets for GSE51615
Status Public on Nov 01, 2013
Title Expression data from rhesus macaque colon, jejunum, and lung
Organism Macaca mulatta
Experiment type Expression profiling by array
Summary The mucosa that lines the respiratory and gastrointestinal (GI) tracts is an important portal of entry for pathogens and provides the frontline of immune defense against HIV infection. Using the simian immunodeficiency virus (SIV) rhesus macaque model, we have performed a comparative analysis of host gene expression in the lung and GI mucosa in response to SIV infection and antiretroviral therapy.
Microarrays were used to characterize changes in gene expression in the colonic, jejunal, and pulmonary (lung) mucosa that occur during chronic SIV infection in the presence or absence of antiretroviral therapy.
 
Overall design Colon, jejunum, and lung tissues from healthy uninfected macaques and macaques with chronic stage SIV infection (+/- therapy) were used for RNA extraction and hybridization on Affymetrix microarrays.
 
Contributor(s) George MD
Citation(s) 24610016
Submission date Oct 23, 2013
Last update date May 12, 2014
Contact name Michael George
E-mail(s) mdgeorge@ucdavis.edu
Organization name University of California, Davis
Department Medical Microbiology and Immunology
Street address 451 Health Sciences Drive
City Davis
State/province CA
ZIP/Postal code 95616
Country USA
 
Platforms (1)
GPL3535 [Rhesus] Affymetrix Rhesus Macaque Genome Array
Samples (32)
GSM1249362 Colon tissue: SIV infected, antiretroviral therapy treated macaque biological rep 1
GSM1249363 Colon tissue: SIV infected, antiretroviral therapy treated macaque biological rep 2
GSM1249364 Colon tissue: SIV infected, antiretroviral therapy treated macaque biological rep 3
Relations
BioProject PRJNA224100

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE51615_RAW.tar 132.1 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table
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