|
| Status |
Public on Feb 02, 2015 |
| Title |
Huntington’s disease biomarker progression profile identified by transcriptome sequencing in peripheral blood |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
In this study we investigated the suitability of blood to identify HD transcriptomic biomarkers, validated the outcome in an independent cohort and derived a first empiric panel of biomarkers capable of predicting HD motor scores. Finally we examined whether patient gene expression profiles could provide information about HD affected biological pathways.
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| |
|
| Overall design |
Examination of differentially expressed genes in peripheral whole blood using linear modelling of gene expression data (3' DGE) against UHDRS total motor scores of Huntington's Disease mutation carriers and controls.
|
| |
|
| Contributor(s) |
Mastrokolias A |
| Citation(s) |
25626709 |
| Submission date |
Oct 28, 2013 |
| Last update date |
May 15, 2019 |
| Contact name |
Anastasios Mastrokolias |
| Phone |
0031715269425
|
| Organization name |
Leiden University Medical Center
|
| Street address |
LUMC, Building 2 Einthovenweg 20 2333 ZC Leiden
|
| City |
Leiden |
| ZIP/Postal code |
2333 ZC |
| Country |
Netherlands |
| |
|
| Platforms (2) |
| GPL10999 |
Illumina Genome Analyzer IIx (Homo sapiens) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
|
| Samples (124)
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|
| Relations |
| BioProject |
PRJNA225101 |
| SRA |
SRP032279 |
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