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Series GSE51994 Query DataSets for GSE51994
Status Public on Oct 20, 2014
Title Spatial Regulation of Gene Expression in Articular Cartilage Assessed by Laser Captured Microdissection and Microarray
Organism Mus musculus
Experiment type Expression profiling by array
Summary We used laser capture microdissection to isolate different zones of the articular cartilage from proximal tibiae of 1-week old mice, and used microarray to analyze global gene expression. Bioinformatic analysis corroborated previously known signaling pathways, such as Wnt and Bmp signaling, and implicated novel pathways, such as ephrin and integrin signaling, for spatially associated articular chondrocyte differentiation and proliferation. In addition, comparison of the spatial regulation of articular and growth plate cartilage revealed unexpected similarities between the superficial zone of the articular cartilage and the hypertrophic zone of the growth plate.
 
Overall design Collecte five biological replications in three superficial, mid zone and deep zones of Articular Cartilage Assessed by Laser Captured Microdissection and Microarray(Superficial Zone vs Mid Zone vs Deep Zone)
 
Contributor(s) Lui JC, Chau M, Chen W, Cheung CF, Hanson J, Rodriguez-Canales J, Nilsson O, Baron J
Citation(s) 25068449
Submission date Nov 01, 2013
Last update date Feb 11, 2019
Contact name WeiPing Chen
E-mail(s) weipingChen@niddk.nih.gov
Phone 301-496-0175
Organization name NIDDK/NIH
Department GCL
Lab Genomics Core Lab
Street address Bldg 8, Room 1A11, NIDDK/NIH
City Bethesda
State/province MD
ZIP/Postal code 20892
Country USA
 
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (14)
GSM1256929 1wk3-SZ
GSM1256930 2wk3-MZ
GSM1256931 4wk4-SZ
Relations
BioProject PRJNA226005

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE51994_RAW.tar 214.5 Mb (http)(custom) TAR (of CEL, CHP)
Processed data included within Sample table
Processed data provided as supplementary file

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