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| Status |
Public on Dec 15, 2013 |
| Title |
Time Course of Young Adults Vaccinated with Meningococcal MCV4 and MPSV4 Vaccines |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
We performed systems analyses of immune responses to the meningococcal polysaccharide (MPSV4) and conjugate (MCV4) vaccines in healthy adults.
The goal was to identify innate gene signatures that correlate to antibody responses induced by these vaccines.
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| Overall design |
Healthy adult volunteers (18-45 years of age) were randomized to be vaccinated subcutaneously with MPSV4 (Menomune®, n=13) or intramuscularly with MCV4 (MenactraTM, n=17) (Sanofi Pasteur, Swiftwater, PA). Whole blood samples were collected using CPT tubes at days 0, 3 and 7 post-vaccination. Peripheral blood mononuclear cells (PBMC) were isolated from fresh blood and used for DNA microarray experiments.
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| Contributor(s) |
Li S, Nakaya HI, Pulendran B |
| Citation(s) |
24336226 |
| Submission date |
Nov 08, 2013 |
| Last update date |
Apr 20, 2018 |
| Contact name |
Shuzhao Li |
| Phone |
1(404)712-2594
|
| Organization name |
Emory University
|
| Department |
Emory Vaccine Center
|
| Lab |
Pulendran Lab
|
| Street address |
954 Gatewood Rd NE
|
| City |
Atlanta |
| State/province |
GA |
| ZIP/Postal code |
30329 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL13158 |
[HT_HG-U133_Plus_PM] Affymetrix HT HG-U133+ PM Array Plate |
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| Samples (90)
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| Relations |
| BioProject |
PRJNA227289 |
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