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| Status |
Public on May 13, 2015 |
| Title |
A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
Genome binding/occupancy profiling by high throughput sequencing
Methylation profiling by high throughput sequencing
|
| Summary |
Our data throw light upon the effect of WRN deficiency on gene expression and epigenomic modification, which indicates aging-associated changes from both genomic and epigenomic level.
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| Overall design |
It was compared between WRN+/+ and WRN-/- in hESCs and hMSCs that the gene expression landscapes and epigenetic modifications(H3K4me3, H3K27me3, H3K9me3 and 5-methylcytosine).
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| |
|
| Contributor(s) |
Li J, Zhang W, Liu X, Liu G, Tang F |
| Citation(s) |
25931448 |
| Submission date |
Nov 12, 2013 |
| Last update date |
May 15, 2019 |
| Contact name |
Jingyi Li |
| E-mail(s) |
lijy201@gmail.com
|
| Organization name |
Peking University
|
| Street address |
Yiheyuan Road, No.5, Haidian District
|
| City |
Beijing |
| ZIP/Postal code |
100871 |
| Country |
China |
| |
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| Platforms (2) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
|
| Samples (22)
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| Relations |
| BioProject |
PRJNA227344 |
| SRA |
SRP032942 |
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