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Series GSE5255 Query DataSets for GSE5255
Status Public on Jul 08, 2006
Title Loss of BMPR2 Signaling in Smooth Muscle in Mouse Lung
Organism Mus musculus
Experiment type Expression profiling by array
Summary Mice expressing a doxycycline-inducible dominant negative BMPR2 transgene expressed only in smooth muscle are activated for one or eight weeks, and compared to transactivator-only mice also fed doxycycline. All mice are 12 weeks of old at sacrifice.
Keywords: time course with SM22-rtTA x tetO7-BMPR2 transgene
 
Overall design Each chip is a pool of three individual mice, to reduce variability. The transactivator-only mice are controls. The other mice all had elevated RV pressures at time of sacrifice. RNA was prepared from whole lung.
 
Contributor(s) Tada Y, Majka S, Carr M, Harral J, Crona D, Kuriyama T, West J
Citation(s) 17369292
Submission date Jul 06, 2006
Last update date Feb 11, 2019
Contact name James West
E-mail(s) j.west@vanderbilt.edu
Organization name Vanderbilt University
Department Medicine
Lab Pulmonary
Street address 4200 E 9TH Ave, Box B133
City Nashville
State/province TN
ZIP/Postal code 37201
Country USA
 
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (6)
GSM118653 Control Female FVB/N
GSM118658 Control Male SM22-rtTA only Lung
GSM119284 Lung from SM22-dnBMPR2 inducible transgenic females activated 1 week
Relations
BioProject PRJNA96473

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