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Series GSE52550 Query DataSets for GSE52550
Status Public on Dec 05, 2013
Title Progressive loss of PGC-1alpha expression in aging muscle potentiates glucose intolerance and systemic inflammation
Organism Mus musculus
Experiment type Expression profiling by array
Summary Decreased mitochondrial mass and function in muscle of diabetic patients is associated with low PGC-1alpha, a transcriptional coactivator of the mitochondrial gene program. To investigate whether reduced PGC-1alpha and oxidative capacity in muscle directly contributes to age-related glucose intolerance, we compared the genetic signatures and metabolic profiles of aging mice lacking muscle PGC-1alpha. Microarray analysis revealed that a significant proportion of PGC-1alpha-dependent changes in gene expression overlapped with age-associated effects, and aging muscle and muscle lacking PGC-1alpha shared gene signatures of impaired electron transport chain activity and TGFbeta signalling.
 
Overall design Gastrocnemius muscle mRNA from young (10 week old) and old (24 month old) wild-type and knock-out (muscle-specific PGC-1alpha, myogenin-cre) C57Bl/6N/6J/129 mice
 
Contributor(s) Sczelecki S, Besse-Patin A, Abboud A, Kleiner S, Laznik-Bogoslavski D, Wrann CD, Ruas JL, Haibe-Kains B, Estall JL
Citation(s) 24280126
Submission date Nov 20, 2013
Last update date Feb 11, 2019
Contact name Benjamin Haibe-Kains
E-mail(s) benjamin.haibe.kains@utoronto.ca
Phone +14165818626
Organization name Princess Margaret Cancer Centre
Department Princess Margaret Research
Lab Bioinformatics and Computational Genomics
Street address 610 University Avenue
City Toronto
State/province Ontario
ZIP/Postal code M5G 2M9
Country Canada
 
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (12)
GSM1269619 BS2011051053
GSM1269620 BS2011051054_2
GSM1269621 BS2011051055
Relations
BioProject PRJNA229363

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE52550_RAW.tar 48.5 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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