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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Nov 22, 2013 |
| Title |
Overexpression of UHRF1 drives DNA hypomethylation and hepatocellular carcinoma |
| Organism |
Danio rerio |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
UHRF1 is an essential regulator of DNA methylation that is highly expressed in many cancers. Using transgenic zebrafish, cultured cells and human tumors, we demonstrate that UHRF1 is an oncogene. RNAseq was used to assess the variation in gene expression between control and experimental samples.
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| Overall design |
Total small RNA from 2 batches of Tg(fabp10:has.UHRF1-GFP)High and age matched Tg(fabp10:nls-mCherry) control 5 dpf zebrafish livers was purified for preparation of high-throughput sequencing libraries.
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| Contributor(s) |
Mudbhary R, Hoshida Y, Chernyavskaya Y, Jacob V, Villanueva A, Fiel MI, Chen X, Kojima K, Thung S, Bronson RT, Lachenmayer A, Revill K, Alsinet C, Sachidanandam R, Desai A, Ukomadu C, Llovet JM, Sadler KC |
| Citation(s) |
24486181 |
| Submission date |
Nov 21, 2013 |
| Last update date |
May 15, 2019 |
| Contact name |
Ravi Sachidanandam |
| E-mail(s) |
ravi.mssm@gmail.com
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| Organization name |
Girihlet Inc.
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| Street address |
2945 Webster St
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| City |
Oakland |
| State/province |
CA |
| ZIP/Postal code |
94609 |
| Country |
USA |
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| Platforms (1) |
| GPL14875 |
Illumina HiSeq 2000 (Danio rerio) |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA229468 |
| SRA |
SRP033231 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE52605_geo_qnorm_values.csv.gz |
222.3 Kb |
(ftp)(http) |
CSV |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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