|
| Status |
Public on Dec 31, 2013 |
| Title |
The effect of a novel form of macrophage colony-stimulating factor (CSF1-Fc) on gene expression in the liver. |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Treatment of mice with daily injections of CSF1-Fc produce a 50% increase in the size of the liver within 5 days. There was extensive proliferation of hepatocytes, similar to that seen following partial hepatectomy.
|
| |
|
| Overall design |
Comparative gene expression profiles of the treated and control livers, alongside macrophages grown in CSF1, indicate extensive infiltration by macrophages in response to CSF1-Fc, and demonstrate that infiltrating macrophages produced several candidate mediators of hepatocyte proliferation.
|
| |
|
| Contributor(s) |
Gow DJ, Sauter KA, Hume DA |
| Citation(s) |
24962162 |
| Submission date |
Nov 21, 2013 |
| Last update date |
Jan 08, 2020 |
| Contact name |
Kristin Sauter |
| E-mail(s) |
kristin.sauter@roslin.ed.ac.uk
|
| Organization name |
Roslin Institute/The University of Edinburgh
|
| Street address |
Easter Bush, Midlothian
|
| City |
Roslin |
| ZIP/Postal code |
EH25 9RG |
| Country |
United Kingdom |
| |
|
| Platforms (1) |
| GPL11533 |
[MoGene-1_1-st] Affymetrix Mouse Gene 1.1 ST Array [transcript (gene) version] |
|
| Samples (5)
|
| GSM1273192 |
Control mouse liver sample replicate 1 |
| GSM1273193 |
Control mouse liver sample replicate 2 |
| GSM1273194 |
CSF1-Fc treated mouse liver sample replicate 1 |
| GSM1273195 |
CSF1-Fc treated mouse liver sample replicate 2 |
| GSM1273196 |
CSF1-Fc treated mouse liver sample replicate 3 |
|
| Relations |
| BioProject |
PRJNA229512 |
Less...
More...