|
| Status |
Public on Dec 25, 2014 |
| Title |
Distinct gene expression profiles between overt GIST and miniGIST |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
In contrast to the paucity of clinic GIST (Gastrointestinal stromal tumor; 0.0014 % happening rate), there is a more than twenty thousand times higher rate for miniGISTs, about ~30% of human population could be identified to have miniGISTs. Exploring the molecular differences between miniGISTs and overt GISTs will help us to understand the transformation mechanisms along with GIST progression, but C-kit and PDGFRA mutations analysis failed to identify the differences between these two groups. Conclusion: miniGISTs have significant distinct gene expression profile with overt GISTs by both unsupervised and supervised analysis. Our finding indicated that c-kit and DOG1 expression are the very early events in the genesis of miniGIST and overt GIST, and miniGIST is a molecular distinct group with overt GIST.
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| Overall design |
Within our study, we collected six miniGISTs with diameter less than 1cm from autopsies and seven overt GISTs from clinic, performed the first system-wide gene expression profiling of miniGISTs and overt GISTs by 3’end RNA Sequencing, and further compared the expression profiles between these two groups.
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| Contributor(s) |
Guo X, Zhu SX, Varma S, Brunner AL, Fletcher JA, West RB, van de Rijn M |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Nov 22, 2013 |
| Last update date |
May 15, 2019 |
| Contact name |
Xiangqian Guo |
| E-mail(s) |
xqguo@stanford.edu
|
| Phone |
650 725 7742
|
| Organization name |
Stanford University
|
| Department |
Department of Pathology
|
| Lab |
vanderijn-west Lab
|
| Street address |
300 Pasteur Dr.
|
| City |
Stanford |
| State/province |
CA |
| ZIP/Postal code |
94305 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL10999 |
Illumina Genome Analyzer IIx (Homo sapiens) |
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| Samples (13)
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| Relations |
| BioProject |
PRJNA229762 |
| SRA |
SRP033276 |
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