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| Status |
Public on Nov 25, 2013 |
| Title |
The mechanism of elevated S100A6 (Calcyclin) Enhances Tumorigenesis in clear cell renal cell carcinoma |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Among all types of urological cancers, the clear cell renal cell carcinoma is the second leading cause of death in adults. This is mainly due to lack of promising prognosis or predictors, and effective target therapy. S100A6 (calcyclin), a member of S100 family of proteins, is reported to be elevated in many types of cancers. In the present study, we analyzed the expression of S100A6 in mRNA, in proteins and tissues. The mechanism of enhancing tumorigenesis was studied to understand the role of S100A6 in clear cell renal cell carcinoma tumorigenesis. Microarray and bioinformatic analyses were performed in the stable transfection of overexpression and knockdown of S100A6, comparing with each empty vector control in order to find the different expression genes and explore the mechanism.
The microarray analysis of clear cell renal cell carcinoma 786-O cell line treated with overexpression and knockdown S100A6.
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| Overall design |
Four samples: overexpression S100A6 sample and vector control sample, knockdown S100A6 and vector control sample, each sample had three replicates.
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| Contributor(s) |
Lyu X |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Nov 25, 2013 |
| Last update date |
Apr 23, 2018 |
| Contact name |
xu zhang |
| Organization name |
PLA general hospital
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| Street address |
Fuxing road
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| City |
Beijing |
| ZIP/Postal code |
100853 |
| Country |
China |
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| Platforms (1) |
| GPL17077 |
Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA229870 |
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