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| Status |
Public on Mar 16, 2015 |
| Title |
Gene expression in aortic roots of wild type versus klotho-deficient mice at 6 weeks of age |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Klotho-deficient mice develop aortic valve annulus calcification by 6 weeks of age. Understanding the molecular basis by which aortic valve calcification is initiated will help define potential molecular targets which may be inhibited to reduce or prevent aortic valve calcification.
Changes in gene expression related to aortic valve annulus calcification were analyzed by comparing gene expression in the aortic roots from wild type versus klotho-deficient mice.
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| Overall design |
Aortic roots, containing the aortic valve, valve annulus, and a portion of the ascending aorta were harvested from klotho-deficient and wild type mice at 6 weeks of age and analyzed by Affymetrix microarray.
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| Contributor(s) |
Wirrig E, Yutzey K |
| Citation(s) |
25722432 |
| Submission date |
Nov 27, 2013 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Elaine Emily Wirrig |
| Organization name |
Cincinnati Children's Hospital Medical Center
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| Department |
Molecular Cardiovascular Biology
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| Lab |
Katherine Yutzey
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| Street address |
240 Albert Sabin Way
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| City |
Cincinnati |
| State/province |
Ohio |
| ZIP/Postal code |
45229 |
| Country |
USA |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA230036 |
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