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| Status |
Public on Nov 28, 2013 |
| Title |
Vitamin D treatment of M.tb. infected macrophages |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
As macrophages are the primary site of Mtb infection and are sites of vitamin D signaling, we have used these cells to understand the molecular mechanisms underlying modulation of the immune response by the hormonal form of vitamin D, 1,25-dihydroxyvitamin D (1,25D).
Microarrays were used to measure the changes in gene expression induced by 1,25D treatment of H37Rv-infected THP-1 cells
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| Overall design |
Cells were infected at an MOI of 5 or left uninfected, and treated with 10^-7 M 1,25D for 24 hours
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| Contributor(s) |
White J, Verway M |
| Citation(s) |
23762029 |
| Submission date |
Nov 27, 2013 |
| Last update date |
Jul 26, 2018 |
| Contact name |
John White |
| E-mail(s) |
john.white@mcgill.ca
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| Organization name |
McGill University
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| Department |
Physiology
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| Street address |
3655 Prom. Sir William Osler
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| City |
Montreal |
| State/province |
QC |
| ZIP/Postal code |
H3G 1Y6 |
| Country |
Canada |
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| Platforms (1) |
| GPL6244 |
[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (12)
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| GSM1276663 |
Uninfected treated with 1,25D, replicate 1 |
| GSM1276664 |
Uninfected treated with 1,25D, replicate 2 |
| GSM1276665 |
Uninfected treated with 1,25D, replicate 3 |
| GSM1276666 |
Infected with H37Rv, replicate 1 |
| GSM1276667 |
Infected with H37Rv, replicate 2 |
| GSM1276668 |
Infected with H37Rv, replicate 3 |
| GSM1276669 |
Infected with H37Rv and treated with 1,25D, replicate 1 |
| GSM1276670 |
Infected with H37Rv and treated with 1,25D, replicate 2 |
| GSM1276671 |
Infected with H37Rv and treated with 1,25D, replicate 3 |
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| Relations |
| BioProject |
PRJNA230131 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE52819_Processed_data.xlsx.gz |
2.7 Mb |
(ftp)(http) |
XLSX |
| GSE52819_RAW.tar |
43.6 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
| Processed data are available on Series record |
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