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Series GSE52890 Query DataSets for GSE52890
Status Public on Sep 01, 2017
Title Infection with Streptococcus pneumoniae triggers progression of pulmonary fibrosis by pneumolysin
Organism Mus musculus
Experiment type Expression profiling by array
Summary A two-hit model of adenoviral vector delivery of active transforming growth factor-β (TGFb) 1 to induce fibrosis in mice in conjunction with treatment of the mice with purified pneumolysin from Streptococcus pneumoniae was applied to characterize the role of this virulence factor on fibrosis perpetuation in mice
The study was supported by a BMBF grant for the German Center for Lung Research, partner site BREATH (Biomedical Research in Endstage and Obstructive Lung Disease Hannover)
Overall design Total RNA of murine lung type II alveolar epithelial cells of AdTGFb1 treated mice challenged with pneumolysin (PLY, n=4) and its non-cytotoxic derivative (PdB, n=3) were extracted and subjected to microarray analysis for contrasts of pneumolysin (PLY) versus control (PdB) treatment.
Contributor(s) Lindig S, Maus UA
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Submission date Dec 02, 2013
Last update date Jun 14, 2018
Contact name S. Lambeck
Organization name JUH
Street address Erlanger Allee 101
City Jena
ZIP/Postal code 07743
Country Germany
Platforms (1)
GPL6885 Illumina MouseRef-8 v2.0 expression beadchip
Samples (7)
GSM1277541 Lung_epithelial_cells_PdB_rep.1
GSM1277542 Lung_epithelial_cells_PdB_rep.2
GSM1277543 Lung_epithelial_cells_PdB_rep.3
BioProject PRJNA230400

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE52890_RAW.tar 3.1 Mb (http)(custom) TAR
GSE52890_non-normalized.txt.gz 793.9 Kb (ftp)(http) TXT
Raw data are available on Series record
Processed data included within Sample table

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