|
| Status |
Public on Feb 23, 2014 |
| Title |
Targeting Csnk1a1 induces selective p53-dependant killing of leukemia stem cells |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
We found found that casein kinase 1 alpha (Csnk1a1), a serine threonine kinase and negative regulator of beta catenin, is essential for leukemia cells in vivo.
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| |
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| Overall design |
We examined the effect of Csnk1a1 knowckdown by gene expression profiling in primary leukemia cells.
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| Contributor(s) |
Järås M, Miller PG, Chu LP, Schneider RK, Puram RV, Al-Shahrour F, Breyfogle J, Fink E, Hartwell KA, McConkey ME, Cowley GS, Root DE, Kharas MG, Mullally A, Ebert BL |
| Citation(s) |
24616378 |
| Submission date |
Dec 03, 2013 |
| Last update date |
Jan 16, 2019 |
| Contact name |
Fatima Al-Shahrour |
| E-mail(s) |
shahrour@broadinstitute.org
|
| Organization name |
Broad Institute of MIT and Harvard
|
| Department |
Cancer program
|
| Street address |
7 Cambridge Center
|
| City |
Cambridge |
| State/province |
MA |
| ZIP/Postal code |
02142 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL6887 |
Illumina MouseWG-6 v2.0 expression beadchip |
|
| Samples (9)
|
| GSM1278262 |
Csnk1a1 knockdown (Csnk1a1-94 shRNA) in LSCs rep1 |
| GSM1278263 |
Csnk1a1 knockdown (Csnk1a1-94 shRNA) in LSCs rep2 |
| GSM1278264 |
Csnk1a1 knockdown (Csnk1a1-94 shRNA) in LSCs rep3 |
| GSM1278265 |
Csnk1a1 knockdown (Csnk1a1-97 shRNA) in LSCs rep4 |
| GSM1278266 |
Csnk1a1 knockdown (Csnk1a1-97 shRNA) in LSCs rep5 |
| GSM1278267 |
Csnk1a1 knockdown (Csnk1a1-97 shRNA) in LSCs rep6 |
|
| Relations |
| BioProject |
PRJNA230476 |
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