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Series GSE5313 Query DataSets for GSE5313
Status Public on Dec 02, 2006
Title Comparative analysis of gene expression in A/J CB versus DBA/2J
Organism Mus musculus
Experiment type Expression profiling by array
Summary We hypothesize that gene expression in the CBs of these two strains of mice are divergent thus contributing to the disparity in the phenotypes. More specifically, (1) genes related to CB function are expressed less in the A/J mice compared to DBA/2J mice; (2) gene expression levels of morphogenic and trophic factors of the CB maybe significantly lower in the A/J mice than the DBA/2J mice. In order to test these hypotheses, we utilized microarray analysis to examine transcriptional differences between CBs of both strains of mice.
Keywords: comparative expression profiling
Overall design . This study utilizes microarray analysis to test these hypotheses. Three sets of CBs were harvested from both strains. RNA was isolated and used for global gene expression profiling (Affymetrix Mouse 430 2.0 array). Statistically significant gene expression was determined as a minimum 6 counts of 9 pairwise comparisons, minimum 1.5-fold change, and p < 0.05.
Contributor(s) Balbir A, Lee H, Okumura M, Biswal S, Fitzgerald R, Shirahata M
Citation(s) 17098806
Submission date Jul 14, 2006
Last update date Feb 11, 2019
Contact name Alexander Balbir
Fax 410-955-0299
Organization name Johns Hopkins Bloomberg School of Public Health
Department Environmental Health Sciences
Lab Division of Physiology
Street address 615 N. Wolfe St. Room E7610
City Baltimore
State/province MD
ZIP/Postal code 21205
Country USA
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (6)
GSM120398 AJ 2-10
GSM120399 AJ4-16
GSM120400 AJ 4-23
BioProject PRJNA96321

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