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Series GSE53162 Query DataSets for GSE53162
Status Public on Dec 12, 2013
Title DNA methylation in postmortem brain samples from autism cases and controls
Organism Homo sapiens
Experiment type Methylation profiling by genome tiling array
Summary We used the Illumina 450KMethylation BeadChip to measure DNA methylation at 485,512 loci across the genome for 40 postmortem brain samples. The purpose of our study was to identify differentially methylated regions (DMRs) associated with autism. Samples included 16 temporal cortex brain tissue samples (6 cases and 10 controls), 11 prefrontal cortex brain tissue samples (6 cases and 5 controls), and 13 cerebellum brain tissue samples (7 cases and 6 controls).
 
Overall design We bisulfute converted DNA from the 40 brain tissue samples, processed, and hybridized them to the Illumina Infinium 450K HumanMethylation450 BeadChip as specificed by the manufacturer.
 
Contributor(s) Ladd-Acosta C, Feinberg AP
Citation(s) 23999529
Submission date Dec 10, 2013
Last update date Mar 22, 2019
Contact name Christine Ladd-Acosta
E-mail(s) claddaco@jhsph.edu
Organization name Johns Hopkins University
Department Epidemiology
Street address 615 N. Wolfe Street, E6518
City Baltimore
State/province MD
ZIP/Postal code 21205
Country USA
 
Platforms (1)
GPL13534 Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482)
Samples (40)
GSM1283234 prefrontal_cortex_43_autism
GSM1283235 prefrontal_cortex_46_control
GSM1283236 prefrontal_cortex_85_autism
Relations
BioProject PRJNA231199

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE53162_RAW.tar 183.1 Mb (http)(custom) TAR
GSE53162_unmethylated_methylated.txt.gz 101.5 Mb (ftp)(http) TXT
Processed data included within Sample table
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