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Series GSE53174 Query DataSets for GSE53174
Status Public on Dec 09, 2016
Title Genome-wide analysis of whole-lung and alveolar macrophages before and after gut microbiome depletion
Organism Mus musculus
Experiment type Expression profiling by array
Summary Pneumonia accounts for more deaths than any other infectious disease worldwide. The intestinal microbiota has emerged as a key defense system by local support of mucosal immunity as well as proposed modulatory effects on systemic immunity. We here investigated the transcriptomes of whole-lungs and alveolar macrophages between untreated and antibiotic treated mice.
Overall design Broad spectrum antuibiotics were used to deplete the gut microbiome of C57BL6 mice. Whole lungs and alveolar macrophages were isolated and differential gene expression analysis was performed on untreated and antibiotic treated samples.
Contributor(s) Scicluna BP, Schuijt TJ
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Submission date Dec 10, 2013
Last update date Jun 14, 2018
Contact name Brendon Paul Scicluna
Organization name Academic Medical Center
Street address Meibergdreef 9
City Amsterdam
ZIP/Postal code 1105AZ
Country Netherlands
Platforms (1)
GPL6885 Illumina MouseRef-8 v2.0 expression beadchip
Samples (32)
GSM1285942 whole lung_untreated_1
GSM1285943 alveolar macrophage_untreated_1
GSM1285944 alveolar macrophage_untreated_2
BioProject PRJNA231772

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE53174_RAW.tar 3.1 Mb (http)(custom) TAR
GSE53174_non-normalized_data.txt.gz 5.4 Mb (ftp)(http) TXT
Raw data are available on Series record
Processed data included within Sample table

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